Monday, December 31, 2012

Pa. railroad calendar delivered 63 years late

SCRANTON, Pa. (AP) ? A northeastern Pennsylvania newspaper has just received a calendar to help ring in the new year ? except the year is 1950.

Scranton's The Times-Tribune reports (http://bit.ly/S23ykD ) a mail carrier delivered it 63 years late without explanation on Friday.

The large tube contained a 1950 Pennsylvania Railroad calendar addressed to James Flanagan, former general manager of The Scranton Times.

The calendar includes a holiday greeting from a railroad executive dated December 1949. Flanagan died that month.

A U.S. Postal Service spokesman says lost mail is sometimes found when a machine is dismantled or office space is renovated.

Times-Tribune publisher Bobby Lynett says he'll see if the Steamtown National Historic Site railroad museum is interested in the calendar. If not, he'll display it in the newspaper's offices.

___

Information from: The Times-Tribune, http://thetimes-tribune.com/

Source: http://news.yahoo.com/pa-railroad-calendar-delivered-63-years-203004733.html

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NBC Washington Anchor Suggests Grisly Crime Scene Photos from Newtown Should Be Public; Compares to Emmett Till Open Casket

Just as the open casket for Emmett Till's funeral in 1955 was a grisly wake-up call to Americans about the need to seriously tackle civil rights issues in America, so grisly photos of the Newtown, Conn., school shooting crime scene could be a ?transformational? moment in the gun?-

Read More Post Published: 30 December 2012
Found in section: Politics

Source: http://yesbuthowever.com/nbc-washington-anchor-suggests-grisly-crime-scene-photos-from-newtown-should-be-public-compares-to-emmett-till-open-casket/

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President's brother speaks out on Colombia talks

(AP) ? A brother of Colombian President Juan Manuel Santos has revealed that the country's largest guerrilla group had initially proposed to hold peace talks within Colombia or in neighboring Venezuela, rather than in Cuba.

Enrique Santos said in an article published in the newspaper El Espectador on Sunday that the government's team had insisted that the talks not be held in Colombia.

"We decided on Cuba for security and above all because it guaranteed confidentiality," Santos wrote in the article.

Representatives of the Colombian government and the Revolutionary Armed Forces of Colombia, or FARC, began discussions in Havana on Nov. 19 seeking a deal to end the country's decades-old conflict. They currently are taking a holiday break and are to resume talks on Jan. 14.

Santos, a journalist and former director of the Colombian newspaper El Tiempo, is not a member of the team involved in the current talks, though he has acted as an adviser to the government negotiators.

He revealed details of earlier discussions with the rebels starting in February 2011. He said he has been involved "in an irreversible way in this process."

Santos said that one especially complicated matter was getting one of the rebel leaders, Jaime Alberto Parra Rodriguez, to make the trip to Cuba for those initial discussions. Santos said the rebels were distrustful of the plans to shuttle away Parra, who is better known by the nom-de-guerre Mauricio Jaramillo or the nickname "El Medico."

"It was very hard to convince the FARC to ... accept putting (Parra) on a helicopter supplied by the state," Santos wrote. "At the time of picking him up, he appeared guarded by more than 50 men armed to the teeth. In the end there was crying by women guerrillas and a farewell ceremony. That was the first big achievement: getting Jaramillo to Havana. That process lasted nearly a year."

Santos said he and others arrived in Havana on Feb. 23, 2011, ahead of their first contacts with the guerrillas, and that after sitting together about 70 times, they finally signed a preliminary accord in August 2012 to launch the peace talks. Until they reached that point, Santos said, "various times we were on the verge of breaking off" the discussions.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-12-30-Colombia-Peace%20Talks/id-7d5d39d648d44f4e8fbf90f0dd3957d3

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S3 Mini "out" in Apple patent suit against Samsung

Name: Lawrence B. Ebert

I'm a patent lawyer located in central New Jersey. I have a J.D. from the University of Chicago and a Ph.D. from Stanford University, where I studied graphite intercalation compounds at the Center for Materials Research. I worked at Exxon Corporate Research in areas ranging from engine deposits through coal and petroleum to fullerenes. An article that I wrote in The Trademark Reporter, 1994, 84, 379-407 on color trademarks was cited by Supreme Court in Qualitex v. Jacobson, 514 US 159 (1995) and the methodology was adopted in the Capri case in N.D. Ill. An article that I wrote on DNA profiling was cited by the Colorado Supreme Court (Shreck case) and a Florida appellate court (Brim case). I was interviewed by NHK-TV about the Jan-Hendrik Schon affair. I am developing ipABC, an entity that combines rigorous IP analytics with study of business models, to optimize utilization of intellectual property. I can be reached at C8AsF5 at yahoo.com.

Source: http://ipbiz.blogspot.com/2012/12/s3-mini-out-in-apple-patent-suit.html

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Sunday, December 30, 2012

NBC Washington Anchor Suggests Grisly Crime Scene Photos from Newtown Should Be Public; Compares to Emmett Till Open Casket

Just as the open casket for Emmett Till's funeral in 1955 was a grisly wake-up call to Americans about the need to seriously tackle civil rights issues in America, so grisly photos of the Newtown, Conn., school shooting crime scene could be a ?transformational? moment in the gun?-

Read More Post Published: 30 December 2012
Found in section: Politics

Source: http://yesbuthowever.com/nbc-washington-anchor-suggests-grisly-crime-scene-photos-from-newtown-should-be-public-compares-to-emmett-till-open-casket/

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Saturday, December 29, 2012

If I Ever Get Rich, I'm Gonna Buy One of These Grills

My friend Russ designs grills for Kalamazoo Outdoor Gourmet, where the starting price is around $14,000 $10,000. He just sent me this video, a glimpse at their manufacturing process. Man, these are sweet pieces of kit—all hand-made in an adorable town in Michigan, able to burn wood, gas, or charcoal. *drool* More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/9XahAKascFU/if-i-ever-get-rich-im-gonna-buy-one-of-these-grills

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WEB STREAMING | DaniWeb

How to develop web streaming in php?

Authored by happygeek in the Web Development forum, this related news story currently has 4 replies, was last posted to 4 weeks ago by seomasterx and has been tagged with the following keywords: web, browser, news, google, chrome, microsoft, internet, ie, client, stats, analysis, market. It begins, ?Over the last couple of days the online media seems to have gone crazy for ...?

firdousahmad

Junior Poster in Training

73 posts since May 2012

Reputation Points: -1

Solved Threads: 3

Skill Endorsements: 0

?

Hi,

You mean video and audio streaming?

You will need to have an ffmpeg, mp4 box, flvtool2,mencoder and mplayer, ffmpeg-php capable server. You can also look into red5 media server as an option.

Additional items you would need is a reliable flash player like the ones offered by jwplayer and flowmotion.

If you have a limited bandwidth on your hosting account, make sure to have your video metadata injected with flvtool2 (flv files only), for the h264 and mp4 you can move the moov atom in the front of the video, by using mp4box. These tools will allow you to pseudo-stream your contents without translating all the media file size into bandwidth consumptions.

Lastly, you will need to know all of the basics of ffmpeg-php and the basics ffmpeg encoding commands.

veedeoo

Practically a Master Poster

620 posts since Oct 2011

Reputation Points: 232

Solved Threads: 101

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?

firdousahmad

Junior Poster in Training

73 posts since May 2012

Reputation Points: -1

Solved Threads: 3

Skill Endorsements: 0

?

You will need to look for a reliable hosting company. This is the hosting company I used for developing video streaming applications.

I think they also have a ready to install FREE video streaming applications e.g. phpmotion, clic bucket, vidiscript and many others.

MORE INFO. NOT RELATED TO YOUR QUESTION
I was one of the developer of the vidiscript open-source version 1.0 to version 1.3, but that is the old version we wrote that is still being distributed by most ffmpeg hosting companies. I was able to released all the bug fixes two years ago 2010 and then it was followed by major fix for php 5.3+ in my last year release.

I wrote version 3.7 of the open source, but got really busy at my schooling, and then I have to trashed bin all of the 3.7 version because I want to write it as a video content management using my own mvc framework with an option of smarty, twig and tinybutstrong template engines. I am still on track for my projected release date by mid 2013. This will be called veedeoo scripts which is an open source.

veedeoo

Practically a Master Poster

620 posts since Oct 2011

Reputation Points: 232

Solved Threads: 101

Skill Endorsements: 8

?

Source: http://www.daniweb.com/web-development/php/threads/444164/web-streaming

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PFT: Shanahan: No one has ever played at RG3's level

Cincinnati Bengals v Pittsburgh SteelersGetty Images

And so another regular season comes to an end.

For some players, it is just a prelude to greater heights in the postseason. For others, it is one last chance to leave a good impression at the end of a disappointing season for the team. And for a final group, it won?t be anything but a chance to put on street clothes festooned with logos to watch a game from the sideline because of an injury.

This post is about that last group of players. The final injury reports for Week 17 are in and we?ve got a look at who?s been ruled out for Sunday and which players are still up in the air.

Buccaneers at Falcons

The Falcons will be without safety William Moore (hamstring) and cornerback Christopher Owens (hamstring) for their playoff tuneup. Wide receiver Roddy White (knee), defensive end Jonathan Babineaux and defensive tackle Corey Peters are all questionable. Guard Roger Allen is doubtful for Tampa with a groin injury.

Jets at Bills?

The Jets ruled out cornerback Aaron Berry (hamstring) for their finale. Tight end Dustin Keller (hamstring), quarterback Greg McElroy (concussion), linebacker Bryan Thomas (chest) and wide receiver Chaz Schilens (knee) are all doubtful. 17 other Jets are probable, while the organization?s future is questionable. Defensive end Mark Anderson?s disappointing first season with the Bills will end with him still benched by a knee injury.

Ravens at Bengals

Cornerbacks Jason Allen (hamstring) and Terence Newman (groin) are questionable for the Bengals. The Ravens have seven questionable players, including wide receiver Anquan Boldin and defensive tackle Haloti Ngata, and are expected to rest some starters ahead of the postseason.

Bears at Lions

Safety Chris Conte (knee) and linebacker Blake Costanzo (hamstring) are out for Chicago and linebacker Brian Urlacher (hamstring) is doubtful after returning to practice on Friday. Running back Matt Forte (ankle) is probable. The Lions won?t have defensive tackle Sammie Hill (toe) and they listed safety Louis Delmas (knee) and cornerback Chris Houston (hamstring/hip) as questionable.

Texans at Colts

Cornerback Alan Ball (foot) remains out for the Texans. Running back Arian Foster is probable after leaving last week?s game with an irregular heartbeat.?Running back Delone Carter (ankle), defensive tackle Antonio Johnson (ankle), defensive end Cory Redding (quad) and center Samson Satele (ankle) are all out for Indy.

Panthers at Saints

It feels like running back Jonathan Stewart has been questionable for the entire season with an ankle injury, so it is fitting that he?ll close out the year that way. A knee injury will keep Saints running back Pierre Thomas out of the lineup and a concussion will keep cornerback Jabari Greer out as well.

Eagles at Giants

If the Giants win on Sunday, they?ll likely do it without cornerback Prince Amukamara (hamstring), defensive tackle Chris Canty (knee) and cornerback Jayron Hosley (quad). The Giants are very thin at if neither Amukamara nor Hosley answers the bell. Safety Kenny Phillips (knee), wide receiver Hakeem Nicks (knee) and defensive end Justin Tuck (shoulder) are all questionable. Eagles defensive tackle Fletcher Cox (concussion) and linebacker Mychal Kendricks (concussion) will miss the final game of their rookie seasons.

Browns at Steelers

The Browns ruled out cornerback?Sheldon Brown (concussion/foot), tight end Jordan Cameron (concussion), quarterback Colt McCoy (shoulder), running back Trent Richardson (ankle) and quarterback Brandon Weeden (shoulder). Tackle?Mike Adams (ankle), cornerback Curtis Brown (ankle), linebacker Marshall McFadden (abdomen) and wide receiver Mike Wallace (hip) will not close out the year for the Steelers.

Jaguars at Titans

Offensive lineman Uche Nwaneri (concussion) is out for the otherwise healthy Jaguars. Running back Chris Johnson (ankle) and wide receiver Kendall Wright (rib) are questionable for the Titans. Local interest is doubtful.

Chiefs at Broncos

A full third of the Chiefs roster is on the injury report, but running back Jamaal Charles (illness) is probable. He?s been the one most worth watching anyway. The Broncos ruled cornerback Tracy Porter out with a concussion and kick returner Trindon Holliday is doubtful with a sprained ankle.

Packers at Vikings

Vikings defensive end Brian Robison (shoulder) and cornerback Antoine Winfield (knee/hand) are both questionable. Running back Adrian Peterson is probable with the abdominal injury he picked up last weekend. Wide receiver Randall Cobb (ankle) is questionable after spending most of the week watching practice. Wide receiver Jordy Nelson is probable to return from a hamstring injury.

Dolphins at Patriots

Wide receiver Davone Bess (back) will miss his third straight game for the Dolphins. Defensive tackle Randy Starks missed another week of practice for non-injury reasons, but played in Week 16. Another masterpiece for Bill Belichick as the Patriots coach turns in 20 questionable players for this weekend. Cornerback Marquice Cole (finger) is actually doubtful, which may mean that finger?s never getting any better.

Raiders at Chargers

The Raiders won?t have quarterback Carson Palmer (ribs/lung) and safety Tyvon Branch (neck/ankle) is questionable. Running back Ronnie Brown (hamstring) is questionable for the home team.

Rams at Seahawks

Cornerback Walter Thurmond (hamstring) is out and cornerback Marcus Trufant is probable to return from the same injury for the Seahawks. The Rams had all players participate fully in their final practice of the year on Friday.

Cardinals at 49ers

Cardinals wide receiver Early Doucet will miss another game with a concussion. Tackle Nate Potter (ankle) is questionable to be defending Brian Hoyer?s blindside. The 49ers are listing defensive lineman Justin Smith (triceps) as doubtful and tight end Vernon Davis (concussion) is questionable.

Cowboys at Redskins

Linebacker Ernie Sims is questionable because of a concussion, but the rest of the Cowboys other than defensive tackle Jay Ratliff (sports hernia surgery) are likely to play. Redskins tackle Tyler Polumbus practiced on Friday and is questionable to return from a concussion.

Source: http://profootballtalk.nbcsports.com/2012/12/28/mike-shanahan-no-one-in-nfl-history-has-played-at-rg3s-level/related/

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APNewsBreak: Sen. Crapo won't fight DUI charge

WASHINGTON (AP) ? U.S. Sen. Michael Crapo, the Idaho Republican arrested on suspicion of drunken driving, doesn't plan to fight the charges when he appears in court in January, a spokesman said Friday.

Meanwhile, results from a secondary blood alcohol test performed at the jail show the conservative three-term senator registered a higher level about an hour after being arrested than when he was first tested by the police officer who stopped him.

Police have said Crapo registered a blood alcohol level of 0.11 percent when he was pulled over early Sunday in the Washington suburb of Alexandria, Va., after running a red light. But a secondary test performed after Crapo was brought to the jailhouse ? the one that will be used in court ? registered at 0.14, nearly twice the legal limit, according to a law enforcement official with knowledge of the arrest. The official wasn't authorized to release information publicly and spoke on condition of anonymity.

"He does not plan to contest the charges," said Crapo spokesman Lindsay Nothern, adding that Crapo has consulted with a local Virginia attorney ahead of his Jan. 4 court hearing.

A blood alcohol level of 0.14 means Crapo tested 1/100 of a percentage point below the level that would have mandated jail time under Virginia law. The legal limit in Virginia, which has strict drunken driving laws, is 0.08 percent.

Crapo has apologized and taken responsibility for the incident in a statement, but he hasn't spoken publicly about the arrest. Crapo returned to Washington from Idaho on Wednesday as lawmakers pursue a solution to the looming fiscal cliff, but he wasn't immediately available to comment Friday.

A number of factors could explain the discrepancy between the preliminary breathalyzer test, performed on the street when Crapo was pulled over shortly after midnight, and the jailhouse test, conducted just before 2 a.m. The higher level at the jailhouse could indicate Crapo was drinking shortly before getting behind the wheel and his body was still absorbing the alcohol. But another possible explanation is that blood alcohol testing simply isn't a perfect science, said Michael Hlastala, a breath testing expert and former physiology professor at the University of Washington.

"It could be consistent with rising blood alcohol levels," Hlastala said. "But it just depends on the way the person was breathing, and other factors."

Alexandria police say Crapo was alone in his vehicle when he ran a red light, was pulled over and failed field sobriety tests. He was taken to the Alexandria jail and released on an unsecured $1,000 bond about 5 a.m. Sunday. Crapo is scheduled to appear in court on Jan. 4 ? the day after the start of the next Congress. Crapo was handily re-elected in 2010 and won't have to run again until 2016.

It's still not clear where Crapo was coming from when he was arrested, and the senator hasn't explained the circumstances of the arrest. Court records show Crapo residing in Southeast Washington, a short drive over the Potomac River from the historic suburb where he was arrested.

The 61-year-old's arrest two days before Christmas stunned colleagues and constituents alike, not only because of his squeaky-clean image but also because the senator, a Mormon, had said previously he abstains from alcohol, in accordance with his church's practices.

Many of Crapo's Republican colleagues, including Sen. Jim Risch, Idaho's senior senator, have come to his defense, suggesting Crapo can overcome the indiscretion and remain a viable leader. Crapo's home-state newspaper, the Idaho Statesman, ran an editorial with the headline: "We can all learn from Sen. Crapo's mistake."

___

Miller reported from Boise, Idaho.

Source: http://news.yahoo.com/apnewsbreak-sen-crapo-wont-fight-dui-charge-221721243--politics.html

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Cholesterol drug shows promise in fighting effects of malaria

Dec. 27, 2012 ? Researchers have discovered that adding lovastatin, a widely used cholesterol-lowering drug, to traditional antimalarial treatment decreases neuroinflammation and protects against cognitive impairment in a mouse model of cerebral malaria. Although there are differences between mouse models of cerebral malaria and human disease, these new findings indicate that statins are worthy of consideration in clinical trials of cerebral malaria, according to an article published in the Dec. 27 issue of PLOS Pathogens.

Malaria, a parasitic infection that is transmitted to humans by the female Anopheles mosquito, is one of the leading infectious diseases worldwide. Cerebral malaria is a severe, potentially fatal neurologic complication of infection by the parasite Plasmodium falciparum. Studies of children with cerebral malaria show that cognitive deficits, such as impaired memory, learning, language, and mathematical abilities, persist in many survivors long after the infection itself is cured.

"Over 500,000 children develop cerebral malaria each year in sub-Saharan Africa, and persistent cognitive dysfunction in survivors is not only a major public health concern, but also a significant socioeconomic burden," says Guy Zimmerman M.D., associate chair for research in the Department of Medicine at the University of Utah and senior co-author on the study. "There is an urgent and unmet medical need for therapies that treat or prevent cognitive impairment in cerebral malaria."

Statins, a class of drugs best known for their ability to lower cholesterol, have also been shown to be active in modulating a variety of immune system responses. In their research, Zimmerman and his Brazilian colleagues evaluated the effect of statins in a mouse model of cerebral malaria. The researchers found that adding a drug called lovastatin to traditional antimalarial therapy prevented cognitive dysfunction in mice infected with cerebral malaria. They discovered that addition of lovastatin decreased white blood cell accumulation and leakiness in blood vessels in the brain. Lovastatin also reduced production of damaging oxygen-containing molecules and other factors that promote inflammation.

"The molecular mechanisms that give rise to cerebral malaria and subsequent cognitive dysfunction are not yet known," says Zimmerman. "However, the fact that statin treatment decreases both injurious blood vessel inflammation and cognitive dysfunction suggests that a combination of vascular and inflammatory triggers leads to cerebral pathology and intellectual deficits."

Zimmerman and his colleagues also studied lovastatin in an experimental model of bacterial sepsis, a severe whole-body inflammatory state that can also lead to cognitive impairment. They found that lovastatin also prevented cognitive impairment after bacterial sepsis.

"Our findings are exciting because the clinical implications extend beyond cerebral malaria to other severe systemic inflammatory syndromes complicated by brain involvement," says Zimmerman. "We believe our observations are the first experimental evidence to support the possibility of using statins to reduce cognitive impairment in critically ill patients."

This study is the latest result of a long-term collaboration between Zimmerman and Dr. Hugo Castro-Faria-Neto and his group at the Oswaldo Cruz Foundation, a Brazilian research institute dedicated to the study, prevention, and treatment of infectious diseases. This collaboration began when Dr. Castro-Faria-Neto was a visiting scientist at the University of Utah. Future research will focus on additional investigation into the molecular mechanisms of cerebral malaria and the responses of key immune cells to malaria toxins, as well as on studies of the systemic inflammatory component of malaria in human patients.

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Story Source:

The above story is reprinted from materials provided by University of Utah Health Sciences, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Patricia A. Reis, Vanessa Estato, Tathiany I. da Silva, Joana C. d'Avila, Luciana D. Siqueira, Edson F. Assis, Patricia T. Bozza, Fernando A. Bozza, Eduardo V. Tibiri?a, Guy A. Zimmerman, Hugo C. Castro-Faria-Neto. Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria. PLOS Pathogens, 2012; 8 (12): e1003099 DOI: 10.1371/journal.ppat.1003099

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/taG56kmSFpM/121227173046.htm

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Friday, December 28, 2012

Samsung updates its ChatON service to version 2.0

Samsung ChatON

Samsung has just updated its universal chat service, ChatON, with a whole host of new features. When first launching the app, users are now greeted with the ability to sign in with their Samsung account, which makes syncing smoother. This means that all of your devices -- up to 5 in total -- with ChatON will receive messages simultaneously, which is a feature you'd expect from this type of service. Version 2.0 has added the ability to send multiple images at once as well as changing the font in the chat room. Samsung has also made improvements to the profile page that lets users have multiple profile images.

The ChatON app is preloaded on all Samsung devices, is available from Samsung Apps and can be downloaded to any device from the Google Play Store at the link above.

Source: Samsung



Source: http://feedproxy.google.com/~r/androidcentral/~3/z4hHER76RBM/story01.htm

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New class of malaria drugs using essential calcium enzyme developed

Dec. 27, 2012 ? Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state. It has been implicated as a factor in muscular dystrophy, AIDS, Alzheimer's disease, multiple sclerosis, and cancer. As such, finding and exploiting calpain inhibitors is an important area of research.

A team from the Perelman School of Medicine, University of Pennsylvania, in collaboration with the University of California at San Francisco and the Department of Biochemistry and Protein Function Discovery at Queen's University, has developed a unique approach to calpain inhibition by mimicking a natural reaction with a synthesized molecule. The work was published in the latest issue of the Journal of the American Chemical Society.

One of calpain's less beneficial functions is that it eases the ability for cellular invaders such as the Plasmodium falciparum parasite, which is responsible for malaria, to exit their hosts and infect other cells. It is this property that caught the attention of Doron Greenbaum, PhD, assistant professor in of Pharmacology, whose laboratory studies how malaria spreads.

"We have an interest in this protein because it's important for Plasmodium development," he explains. "We initially found that calpain played a role in parasites being able to get out of their host cell, so we became interested in inhibitor development for human calpains."

Greenbaum and his collaborators examined the crystal structure of calpastatin, a natural calpain inhibitor, for clues. "We decided to take a different tack on inhibitor development, which has traditionally been designing small peptide-like inhibitors that fit across an enzyme's active site," Greenbaum says. Studying the configuration of how calpastatin bound to the active site of the calpain complex, "we found that there was a small alpha-helix that fit into the active site of the calpain enzyme."

Researchers have never before used an alpha-helix structure to inhibit a protease. "Traditionally people thought that alpha-helices normally make horrible inhibitors because it was thought that proteases don't like to bind to them preferring to bind motifs called a beta-sheet," Greenbaum notes. The research team created a peptide with an alpha-helical shape that would fit into the active site of the calpain protease.

The team set out to find a way to stabilize the helix by modifying it with a cross-linking peptide. They screened twenty-four commercially available crosslinkers, identifying five that succeeded in stabilizing the helix. They selected one in particular -- dibromo-m-xylene c15 -- and used it to mimic a protein-protein interaction between calpain and calpastatin. By binding to the active site and thus blocking it, the synthesized molecule inhibits the calpain enzyme from binding with other molecules that permit it to wreak its damaging effects.

"It's the first example of an alpha-helical inhibitor of any protease," Greenbaum says. "Previously no one's ever tried using an alpha-helical motif. It opens up a new way of inhibiting proteases." Aside from being a good inhibitor, the stabilized alpha-helical molecule is also highly specific for calpains, while ignoring other, similar-shaped proteases, thus hopefully downplaying potential side effects if used in humans.

Greenbaum and his collaborators are building upon this initial success to expand the basic concept to a wide range of protease molecules. "The next step is to show how this concept can be generalized to multiple classes of proteases, many of which are pharmaceutically of great interest," he explains. "It's not a single-hit wonder."

The extension of the technique to stabilize the alpha-helix shape in enzymes to other proteins could eventually lead to practical drug therapies for a wide range of diseases, predict the researchers.

This work was supported by funding from the Penn Genome Frontiers Institute; the National Institutes of Health (1R01AI09727301A1; 5T32GM071339; and GM54616); the Canadian Institutes for Health Research; and an R.J. Wilson Fellowship.

Co-authors are Hyunil Jo, Nataline Meinhardt, Yibing Wu, Swapnil Kulkarni, Xiaozhen Hu, Kristin E. Low, Peter L. Davies, and William F. DeGrado.

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Story Source:

The above story is reprinted from materials provided by University of Pennsylvania School of Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Hyunil Jo, Nataline Meinhardt, Yibing Wu, Swapnil Kulkarni, Xiaozhen Hu, Kristin E. Low, Peter L. Davies, William F. DeGrado, Doron C. Greenbaum. Development of ?-Helical Calpain Probes by Mimicking a Natural Protein?Protein Interaction. Journal of the American Chemical Society, 2012; 134 (42): 17704 DOI: 10.1021/ja307599z

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/USYm4lfCvzQ/121227142953.htm

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Snowstorm heads east after South twisters; 3 dead

MOBILE, Ala. (AP) ? An enormous storm system that dumped snow and sleet on the nation's midsection and unleashed damaging tornadoes around the Deep South began punching its way toward the Northeast on Wednesday, slowing holiday travel.

Post-Christmas travelers braced for flight delays and a raft of weather warnings for drivers, a day after rare winter twisters damaged buildings in Louisiana and Alabama. The storm system headed from the Gulf Coast to New England has been blamed for three deaths and several injuries, though no one was killed outright in the tornadoes. The storms also left more than 100,000 without power for a across the South, darkening Christmas celebrations.

Severe thunderstorms were forecast for the Carolinas while a line of blizzard and winter storm warnings stretched from Arkansas up the Ohio River to New York and all the way to Maine.

Rick Cauley's family was hosting relatives for Christmas when tornado sirens went off in Mobile. Not taking any chances, he and his wife, Ashley, hustled everyone down the block to take shelter at the athletic field house at Mobile's Murphy High School in Mobile.

It turns out, that wasn't the place to head.

"As luck would have it, that's where the tornado hit," Cauley said. "The pressure dropped and the ears started popping and it got crazy for a second." They were all fine, though the school was damaged, as were a church and several homes, but officials say no one was seriously injured.

Camera footage captured the approach of the large funnel cloud.

Mobile was the biggest city hit by numerous twisters. Along with brutal, straight-line winds, the storms knocked down countless trees, blew the roofs off homes and left many Christmas celebrations in the dark. Torrential rains drenched the region and several places saw flash flooding.

More than 325 flights around the U.S. were canceled as of Wednesday morning, according to the flight tracker FlightAware.com. The cancelations were mostly spread around airports that had been or soon would be in the path of the storm.

Holiday travelers in the nation's much colder midsection battled treacherous driving conditions from freezing rain and blizzard conditions from the same fast-moving storms. In Arkansas, highway department officials said the state was fortunate the snowstorm hit on Christmas Day when many travelers were already at their destinations.

Texas, meanwhile, dealt with high winds and slickened highways.

On Tuesday, winds toppled a tree onto a pickup truck in the Houston area, killing the driver, and a 53-year-old north Louisiana man was killed when a tree fell on his house. Icy roads already were blamed for a 21-vehicle pileup in Oklahoma, and the Highway Patrol there says a 28-year-old woman was killed in a crash on a snowy U.S. Highway near Fairview.

Trees fell on homes and across roadways in several communities in southern Mississippi and Louisiana. Mississippi Gov. Phil Bryant declared a state of emergency, saying eight counties reported damages and some injuries.

It included McNeill, where a likely tornado damaged a dozen homes and sent eight people to the hospital, none with life-threatening injuries, said Pearl River County emergency management agency director Danny Manley.

The snowstorm that caused numerous accidents pushed out of Oklahoma late Tuesday, carrying with it blizzard warnings for parts of northeast Arkansas, where 10 inches of snow was forecast. Freezing rain clung to trees and utility lines in Arkansas and winds gusts up to 30 mph whipped them around, causing about 71,000 customers to lose electricity for a time.

Christmas lights also were knocked out with more than 100,000 customers without power for at least a time in Texas, Arkansas, Oklahoma, Mississippi, Louisiana and Alabama.

Blizzard conditions were possible for parts of Illinois, Indiana and Kentucky up to Cleveland with predictions of several inches to a foot of snow. By the end of the week, that snow was expected to move into the Northeast with again up to a foot predicted

Jason Gerth said the Mobile tornado passed by in a few moments and from his porch, he saw about a half-dozen green flashes in the distance as transformers blew. His home was spared.

"It missed us by 100 feet and we have no damage," Gerth said.

In Louisiana, quarter-sized hail was reported early Tuesday in the western part of the state and a WDSU viewer sent a photo to the TV station of what appeared to be a waterspout around the Lake Pontchartrain Causeway in New Orleans. There were no reports of crashes or damage.

Some mountainous areas of Arkansas' Ozark Mountains could get up to 10 inches of snow, which would make travel "very hazardous or impossible" in the northern tier of the state from near whiteout conditions, the weather service said.

The holiday may conjure visions of snow and ice, but twisters this time of year are not unheard of. Ten storm systems in the last 50 years have spawned at least one Christmastime tornado with winds of 113 mph or more in the South, said Chris Vaccaro, a National Weather Service spokesman in Washington, via email.

The most lethal were the storms of Dec. 24-26, 1982, when 29 tornadoes in Oklahoma, Missouri, Arkansas, Tennessee and Mississippi killed three people and injured 32.

In Mobile, a large section of the roof on the Trinity Episcopal Church is missing and the front wall of the parish wall is gone, said Scott Rye, a senior warden at the church in the Midtown section of the city.

On Christmas Eve, the church with about 500 members was crowded for services.

"Thank God this didn't happen last night," Rye said.

___

Associated Press writers Jay Reeves in Birmingham, Ala., Jeff Amy in Atlanta, Ramit Plushnick-Masti in Houston, Chuck Bartels in Little Rock, Ark., Janet McConnaughey in New Orleans and AP Business Writer Daniel Wagner in Washington, contributed to this report.

Source: http://news.yahoo.com/snowstorm-heads-east-south-twisters-3-dead-092714438--finance.html

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Thursday, December 27, 2012

Taylor Swift Named Most Charitable Celebrity of 2012

Source: http://www.thehollywoodgossip.com/2012/12/taylor-swift-named-most-charitable-celebrity-of-2012/

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NCKU's i-Transport robot wheelchair helps riders reach full height

NCKU's iTransport robot wheelchair helps riders reach loftier heights

Those who have to use a wheelchair are often bound to the elevation of the seat if they want to reach something, which isn't fair when some parts of our world are still built for standing height. Taiwan's National Cheng Kung University is redressing that imbalance with the i-Transport. Its robotic vehicle can raise the driver to an upright level and shift them into a better position to grab objects that wouldn't otherwise be at arm's length. The added independence doesn't stop with the assistance, either, as the i-Transport carries its own blood pressure and breathing monitors to keep checkups to a minimum. NCKU hasn't said how likely it is that we'll see the robot enter mass production, but we hope it forges ahead -- the potential freedom would be worth the effort.

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Source: NCKU

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/_xrBxvB0XOI/

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Obama, Democrats, winning over public on 'fiscal cliff' (Los Angeles Times)

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NuVo P100 Wireless Player


The NuVo P100 Wireless Player ($479 list) plays little brother to the flagship $600 P200 Wireless Player. Like its brethren, the P100 is a combination stereo amplifier and wireless?media hub dedicated to music playback, with support for dual-band Wi-Fi and MIMO. The idea is that you buy P100s for smaller rooms with smaller speakers, and P200s for larger rooms, and then control the entire NuVo system from your iOS or Android device, with the ability to play back different music streams on each system.

The P100 is?not a particularly good value, though, thanks to its still-high price, weaker amplifier, and smaller feature set. But it's fine for use in smaller rooms that don't need the P200's additional power or Bluetooth wireless streaming.

Design and Connections
For more on how the NuVo system works, start with our P200 review. Here, I'll focus on the differences between the two devices.

The 1.35-pound P100 looks like a shrunken P200, measuring 1.65 by 7.36 by 4.53 inches (HWD). Like its larger sibling, it's made entirely of black plastic, with opposing vertical and horizontal curves on the left and right edges of the front panel, respectively. On the front, there's one less button, since the P100 lacks Bluetooth streaming capability; instead, you get just the pair of volume capacitive touch buttons and the Mute button, along with the combination power and status LED.

Around back, everything is almost the same as well. You get an Ethernet port, a USB port, four gold 5-way binding posts, standard-size 3.5mm line in and line out jacks, a hardware power switch, and a port for the power cord. The power supply is still internal, which is a nice touch, as no one likes wall warts. The only difference from the P200 is that the P100 lacks the 3.5mm setup mic port, which isn't a big loss, as the P200 manual says the port is for "future use" only.

Setup, Performance, and Conclusions
You set up the P100 in much the same fashion as the P200. The biggest bummer in the P100's setup process is also what makes it such a good unit for wireless streaming of lossless audio: It requires the additional GW100 Gateway, which is another $199, if you want to use the system wirelessly. Otherwise, you have to plug it straight into your wireless router with an Ethernet cable. Aside from that, the setup process is the same, via the free iOS or Android app that you download and install on your mobile device. NuVo P100 Back

The P100's 20-watt-per-channel amplifier is considerably less powerful than the 60-watt x2 amp in the P200. That's by design, of course; the P100 is meant for use in a smaller room in the house, such as a home office, a bedroom, or a small study, and still sounds good in that context. One other note: Unlike the P200, the P100 isn't capable of driving 4 ohm speakers; it only works with 6 ohm and 8 ohm speakers. Most of the time, this isn't a problem, but if you've got an old pair of PSB Stratus Minis or similar bookshelf speakers, you'll want to go with the P200.

My biggest problem with the P100, though, is its price. The $600 P200 was already expensive, but you lose quite a lot for just $120 in savings. The P200 has a much more powerful amp, aptX Bluetooth streaming capability, and the Audyssey dynamic volume circuitry. Still, if you're committing to a multi-room NuVo Wireless Audio System, the P100 could be just the thing for the smaller rooms in your home.

More Media Hub Reviews:
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??? NuVo P200 Wireless Player
??? Roku Stick
??? Belkin @TV Plus
??? Sling Media Slingbox 350
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Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/2zq6wBnLRbY/0,2817,2413362,00.asp

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Tuesday, December 25, 2012

Simple Abundance Exercises Can Change Your Mindset ...

Article title: Simple Abundance Exercises Can Change Your Mindset
Article Category: Self-Improvement

5 free summer clipart illustration of a happy smiling sun Simple Abundance Exercises Can Change Your Mindset

When you feel more prosperous, you will lead life of improved health, happiness and prosperity. However, when most of us think about our finances, most of the time we don?t have thoughts of prosperity.
Continue reading this article?

Source: http://www.medicalguide.pro/3374/simple-abundance-exercises-can-change-your-mindset-5.html

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Novel legalistic ? education: Right to Culture ? Mike Linksvayer

What passes for copyright education aimed at the general public (caveat: aiming to educate about copyright out of context of broader info- and social-policy is misguided, but I?ll leave that be for now, and the campaign described fortunately doesn?t mention copyright) might be categorized along the following:

  • Legalistic (explaining what can or can?t be done within current law) and/or normative
  • Blunt (e.g., downloading is a crime, copying isn?t theft) and/or turgid (e.g., how to comply with the DMCA, what maybe fair use, how public copyright licenses work)
  • Tilted in favor of more or less restriction

It?s easy to think of examples of examples of all of the resulting combinations, except for one: legalistic, blunt, and favoring less restriction. The nearest I can recall were the EFF ?MP3 is not a crime? and ?coding is not a crime? stickers, but it is hard to know what to take from those without knowing background stories (and I can?t recall what the MP3 one referred to), and ?not a crime? is not very positive. Thus I find the Modern Poland Foundation?s Right to Culture campaign interesting (emphasis added):

The Modern Poland Foundation has launched a social campaign ?The Right to Culture?. Its main goal is to enhance public awareness of freedoms under the copyright law.

The message is carried by three simple statements which are consistent with the copyright law, but often wrongly seen as a violation:

I have the right to copy books.
I have the right to download films.
I have the right to share music.

The three sentences ? in speech bubbles ? have been placed on the Warsaw subway cars? windows. They also point to the project website prawokultury.pl, where one can find detailed information explaining legal provisions of the Copyright Law in Poland.

Art. 23 of the Copyright Law states that one is ?permitted to use free of charge the work, which has been already disseminated for purposes of private use without the permission of the author.? This includes ?the use of single copies of the work by a group of persons staying in a personal interrelation with each other, including in particular blood relation, kinship or a social relationship.? This means that restrictions concerning everyday activities such as copying books or e-books, downloading films or sharing music or files are not unconditional. Therefore, it is legal to make a copy of a book, download a film from the Internet or send a music album to a friend.

Go to the announcement for links and more.

Perhaps similarly legalistic, blunt, and favoring less restriction campaigns should be considered for your jurisdiction.

Source: http://gondwanaland.com/mlog/2012/12/24/right-to-culture/

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Christmas Past?A Family History Scrapbook - The Pendleton ...

For Christmas 1984, my dad gave each of my siblings and me a scrapbook that he put together filled with family photos, copies of newspaper clippings and letters, playbills, cards we had given him and our mom, report cards (yikes), you-name-it. A lot of the photos in each scrapbook were geared toward the recipient but also included a few photos of the other siblings. He also put in photos of himself and our mom, our grandparents, aunts, uncles, cousins, and our children. At the end of each scrapbook was a card with a special note from our dad. It?s one of the best presents I?ve ever received. Over the years, I would get my scrapbook out and pour over it, and I continued collecting memorabilia to add to mine.

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SCAN2963 Catherine John Helen Missy Andy 1984 adjusted

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Here we are Christmas day 1984 about to open our gifts?the wonderful scrapbooks that our dad made for us filled with family memorabilia. You can see how huge they were! From left to right: me, John, Helen, Missy, and Andy.

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SCAN2964 John Helen Missy 1984 adjusted

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John, Helen, and Missy looking through their scrapbooks.

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SCAN2965 Helen 1984 adjusted

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Helen looking through her scrapbook.

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A page from Helen?s scrapbook with photographs of our mom when she was a kid.

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Another page from Helen?s scrapbook. This has graduation photos of our parents and a newspaper article when they graduated from Valdosta State University in the early 1970s?our mom with a degree in nursing (she already had a degree in art) and our dad with a degree in English. Since Helen practiced ballet for 15 years, Dad also included photos of her and a playbill from her recitals.

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When I moved to Alaska, I left my scrapbook behind with the intention of one day taking it back with me after one of my visits to Valdosta. Well, that never happened because it was too big to fit in my suitcase. I?m back in Valdosta now, and I look forward to getting my scrapbook out of storage to pour over again! What a wonderful way to preserve family history!

Catherine

Source: http://www.pendletongenealogypost.com/2012/12/christmas-pasta-family-history-scrapbook.html

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Monday, December 24, 2012

The O.C.D. Experience Workspace

The O.C.D. Experience WorkspaceToday's featured workspace comes from Justin Klosky of organizing service O.C.D. Experience. He organized his home office to perfect, showing exactly what he wanted and nothing that he didn't. You won't find a single wire anywhere. Justin explains his choices:

I consider everything when it comes to the way I setup my personal space. It is part of my OCD. Our entire place has a specific purpose for living. It has been that way since I was a child. My favorite space right now is the O.C.D. Experience office. On the ground, I put in an red area rug, which fuels me, and an ottoman that doubles as a two-person window seat and storage for all our office supplies. Cork boards line the walls for organized visions, goals, and creative expectations. I brought in a large citrine crystal to add life and career energy, as well as "El Jeffe," our security guard - an office plant of five years, who has traveled from NY to LA, LA to NY, and NY back. The best part of the office is the desk system I built from scratch; I've labeled it the "O.C.D. Desk System." (Did I mention that you can't see one wire, as the desk hides them all?)

If you want to read more about Justin's workspace and see more photos, check out the full post over at Herman Miller Lifework. It even includes some helpful organization tips for the holidays.

If you have a workspace of your own to show off, post them to #workspaceshowcase. Make sure any photos you include are at least 640x360. Keeping them to 16:9 helps, too! Include a little text about the stuff you used, how you came up with the design, and any other relevant details. If your clever organization and good design sense catches our eye, you might be the next featured workspace.

Home-Office Tour: Justin Klosky of O.C.D. Experience | Herman Miller Lifework

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/VrpZTrNv_9s/the-ocd-experience-workspace

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Can a Mind Body Spirit Detox Help Psychological Health and fitness ...

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Brookhaven Retreat Helps Women Prepare Legal Plans for Mental ...

http://nonamos.com/brookhaven-retreat-helps-women-prepare-legal-plans-for-men...>Brookhaven Retreat Helps Women Prepare Legal Plans for Mental Health?Back gay men, The Life, HIV News | Nonamos

Mental Health Recovery

Knoxville, TN (PRWEB) December 18, 2012

With the new year fast approaching, many women are trying to refresh their lives and are making resolutions for a happier, healthier 2013. For women with mental health or substance abuse issues, however, long-ignored roadblocks can impede achievement of a healthy start. Family, friend, fitness and finance goals are difficult to focus on when women are facing medical or legal troubles.

Women with mood disorders or substance abuse issues may have important legal issues that require immediate attention. Mood disorders often lead to legal repercussions; for example, women with bipolar disorder may take on excessive financial burdens, face discrimination at work or experience arrest. Women with mood disorders may also face legal issues regarding the effects of violence, divorce or substance abuse.

Brookhaven Retreat teaches women in its residential treatment facility various ways of coping with mood disorders and protecting their futures so that mental health issues do not prevent them from living full and safe lives. Only then can women focus on creating a happy new year. Once medical safety has been assured, women learn to protect their future, possessions, families and medical health with a variety of legal options. Key options Brookhaven Retreat teaches women in its program include:

Have a Lawyer: Women with mental health issues should have a lawyer who is familiar with their medical history and directions should something occur. Should women face discrimination or require hospitalization, this lawyer would serve as a contact for placing protective measures into effect.

Create Advanced Directives: Advanced directives serve to communicate preferences for mental health treatment if women are unable to give consent themselves. Because mental health issues may crop up unexpectedly, these legal documents specify the care women wish to receive and the types of treatment and medication they do not wish to be given. Advanced directives should be part of a woman?s medical record. Her doctors and health care proxy should be given copies so that, should she be admitted to a mental health facility, her specific instructions are easily accessible.

Power of Attorney: Women with mood disorders can be resistant about continuing necessary medication. Giving a trusted loved one or family member power of attorney grants them the ability to admit a woman to a psychiatric facility should she display symptoms dangerous to her well-being. This is especially important for women complying with terms of probation who may resist taking necessary precautions.

It is important that women with mental health issues consider the resources required for long-term emotional recovery. Often these resources should include legal support.

Brookhaven Retreat teaches the women in its residential treatment facility that when focusing on a path to happiness, they need to create a plan to prevent future consequences and protect the lives they are creating. Familiarity with the legal system and familiarity with a lawyer both help safeguard long-term wellness.

About Brookhaven Retreat

Brookhaven Retreat is a women?s treatment center nestled on a naturally beautiful 48-acre site secluded in the foothills of the Great Smoky Mountains. It has helped hundreds of women across the United States overcome depression, trauma, anxiety, substance use and a range of other behavioral health challenges. Brookhaven?s Founder, Jacqueline Dawes, has predicated its gender-specific treatment on ?healing emotional breakage? for women. In this way, she has established a sanctuary and a place where women can feel safe, secure and cared for by a staff of highly trained professionals.

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Sunday, December 23, 2012

Happy birthday, Lady Bird (Offthekuff)

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There's No Place For Leadership Excuses - wise self ...

Great leaders cannot enjoy all the luxuries and indulgences that those not in positions in leadership. They must understand that there is never any place for either excuses or blaming others, when it comes to being a true and effective leader. Great leadership is never about personal popularity, but rather about doing the right thing, and having the guts to attempt to accomplish what others refuse to even try to do. George W. Carver stated, "Ninety - nine percent of failures come from people who have the habit of making excuses." Since great leaders are, by necessity and definition, positive thinkers with a can - do attitude, they must never approach issues thinking about failing. The most effective leader is always the one that focuses on his vital vision, in order to create important and relevant goals, that motivate others to care more and do more for his organization. When one is a real leader, there is no place for blaming or making excuses!

1. Why do weak individuals spend so much time, effort and resources using excuses, and resorting to blaming others? My over three decades of involvement with well over a thousand leaders and/ or potential leaders, has taught me that excuses are used as a fall -back position, when someone in a leadership position either lacks the self - confidence, commitment, insight or inner strength to do what is needed to enhance his organization. Invariably, those that rely on excuses are the ones that never formulate thorough actionable plans, and look for short cuts to actual leadership. The reality is that there are no short cuts to leadership, but that being an effective leader is a process that requires step - by - step actions and behaviors.

2. One of the things that those ascending to positions of leadership is that being a leader requires a significant commitment. This commitment is in terms of time, resources, personal sacrifice, attitude, behavior, absolute integrity, and striving to be the best leader one can possibly be. Unfortunately, far too many individuals attain leadership roles, either unprepared or uncommitted. Most of these individuals are well meaning, but either lack the training, commitment, or inner strength that true leaders possess. If you witness resort to blame or excuses, realize that individual is not a true leader!

Some individuals spend so much time and effort making excuses or blaming others that they waste precious time, efforts and resources, that could and should be used elsewhere. Leaders must hold themselves responsible for their actions, as well as the actions of whatever happens under their watch. Blame and excuses pay no organizational dividends!

Source: http://wiseselfimprovement.blogspot.com/2012/12/there-no-place-for-leadership-excuses.html

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